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It is synthesized from the amino acids lysine and methionine, while smaller amounts are also obtained from foodprimarily animal-based sources

The people who found closer to 50% in their urine probably had a slight vitamin B12 deficiency, and some of the vitamin was stored for later use

The exact mechanism can vary depending on the product and formulation, but they are generally believed to work by either reducing the amount of melanin in the iris or by depositing pigments that alter the eye's appearance

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IGF-1 is the primary marker monitored